Capitalization of biological abbreviations at the beginning of a sentence





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In the beginning of a sentence, should I capitalize abbreviations such as the following:




  • hPSC (human pluripotent stem cell)

  • mESC (mouse embryonic stem cell)

  • rDNA (recombinant deoxyribonucleic acid)


I have seen both lower and upper case for the two first, while rDNA always seems to be in lower case. I'm curious which is the linguistically correct form.










share|improve this question























  • Wikipedia, at least, seems to use the lowercase letter at the beginning of a sentence, for example see the article on mRNA: en.wikipedia.org/wiki/MRNA

    – jbeldock
    Apr 8 '13 at 23:46






  • 2





    Apparently, the Chicago Manual of Style's 16th edition includes a new provision permitting sentences beginning with a brand name (e.g. iPad, iPod) which starts with a lowercase letter to retain the lowercase letter: chicagomanualofstyle.org/about16_rules.html. This might be analogous.

    – jbeldock
    Apr 8 '13 at 23:51











  • Yeah, I use the same approach as Wikipedia on this one. I am, however, curious if there exist a correct and incorrect approach. I don't think the iPad rule applies since these are abbreviations rather than names, but it's an interesting one nonetheless.

    – joelostblom
    Apr 8 '13 at 23:58











  • We also see this in mathematics. Do not begin a sentence with a variable like x . Instead, re-word. Some extra meaningless word may be used. "Now x is..." or "Then x is..." or "Note x is..."

    – GEdgar
    yesterday













  • This is a style issue, rather than "correctness". If you are writing for someone else (eg. a journal, then check their guidelines). If there are no such guidelines, then choose your style and be consistent.

    – James Random
    yesterday


















4















In the beginning of a sentence, should I capitalize abbreviations such as the following:




  • hPSC (human pluripotent stem cell)

  • mESC (mouse embryonic stem cell)

  • rDNA (recombinant deoxyribonucleic acid)


I have seen both lower and upper case for the two first, while rDNA always seems to be in lower case. I'm curious which is the linguistically correct form.










share|improve this question























  • Wikipedia, at least, seems to use the lowercase letter at the beginning of a sentence, for example see the article on mRNA: en.wikipedia.org/wiki/MRNA

    – jbeldock
    Apr 8 '13 at 23:46






  • 2





    Apparently, the Chicago Manual of Style's 16th edition includes a new provision permitting sentences beginning with a brand name (e.g. iPad, iPod) which starts with a lowercase letter to retain the lowercase letter: chicagomanualofstyle.org/about16_rules.html. This might be analogous.

    – jbeldock
    Apr 8 '13 at 23:51











  • Yeah, I use the same approach as Wikipedia on this one. I am, however, curious if there exist a correct and incorrect approach. I don't think the iPad rule applies since these are abbreviations rather than names, but it's an interesting one nonetheless.

    – joelostblom
    Apr 8 '13 at 23:58











  • We also see this in mathematics. Do not begin a sentence with a variable like x . Instead, re-word. Some extra meaningless word may be used. "Now x is..." or "Then x is..." or "Note x is..."

    – GEdgar
    yesterday













  • This is a style issue, rather than "correctness". If you are writing for someone else (eg. a journal, then check their guidelines). If there are no such guidelines, then choose your style and be consistent.

    – James Random
    yesterday














4












4








4








In the beginning of a sentence, should I capitalize abbreviations such as the following:




  • hPSC (human pluripotent stem cell)

  • mESC (mouse embryonic stem cell)

  • rDNA (recombinant deoxyribonucleic acid)


I have seen both lower and upper case for the two first, while rDNA always seems to be in lower case. I'm curious which is the linguistically correct form.










share|improve this question














In the beginning of a sentence, should I capitalize abbreviations such as the following:




  • hPSC (human pluripotent stem cell)

  • mESC (mouse embryonic stem cell)

  • rDNA (recombinant deoxyribonucleic acid)


I have seen both lower and upper case for the two first, while rDNA always seems to be in lower case. I'm curious which is the linguistically correct form.







capitalization abbreviations






share|improve this question













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asked Apr 8 '13 at 23:33









joelostblomjoelostblom

13817




13817













  • Wikipedia, at least, seems to use the lowercase letter at the beginning of a sentence, for example see the article on mRNA: en.wikipedia.org/wiki/MRNA

    – jbeldock
    Apr 8 '13 at 23:46






  • 2





    Apparently, the Chicago Manual of Style's 16th edition includes a new provision permitting sentences beginning with a brand name (e.g. iPad, iPod) which starts with a lowercase letter to retain the lowercase letter: chicagomanualofstyle.org/about16_rules.html. This might be analogous.

    – jbeldock
    Apr 8 '13 at 23:51











  • Yeah, I use the same approach as Wikipedia on this one. I am, however, curious if there exist a correct and incorrect approach. I don't think the iPad rule applies since these are abbreviations rather than names, but it's an interesting one nonetheless.

    – joelostblom
    Apr 8 '13 at 23:58











  • We also see this in mathematics. Do not begin a sentence with a variable like x . Instead, re-word. Some extra meaningless word may be used. "Now x is..." or "Then x is..." or "Note x is..."

    – GEdgar
    yesterday













  • This is a style issue, rather than "correctness". If you are writing for someone else (eg. a journal, then check their guidelines). If there are no such guidelines, then choose your style and be consistent.

    – James Random
    yesterday



















  • Wikipedia, at least, seems to use the lowercase letter at the beginning of a sentence, for example see the article on mRNA: en.wikipedia.org/wiki/MRNA

    – jbeldock
    Apr 8 '13 at 23:46






  • 2





    Apparently, the Chicago Manual of Style's 16th edition includes a new provision permitting sentences beginning with a brand name (e.g. iPad, iPod) which starts with a lowercase letter to retain the lowercase letter: chicagomanualofstyle.org/about16_rules.html. This might be analogous.

    – jbeldock
    Apr 8 '13 at 23:51











  • Yeah, I use the same approach as Wikipedia on this one. I am, however, curious if there exist a correct and incorrect approach. I don't think the iPad rule applies since these are abbreviations rather than names, but it's an interesting one nonetheless.

    – joelostblom
    Apr 8 '13 at 23:58











  • We also see this in mathematics. Do not begin a sentence with a variable like x . Instead, re-word. Some extra meaningless word may be used. "Now x is..." or "Then x is..." or "Note x is..."

    – GEdgar
    yesterday













  • This is a style issue, rather than "correctness". If you are writing for someone else (eg. a journal, then check their guidelines). If there are no such guidelines, then choose your style and be consistent.

    – James Random
    yesterday

















Wikipedia, at least, seems to use the lowercase letter at the beginning of a sentence, for example see the article on mRNA: en.wikipedia.org/wiki/MRNA

– jbeldock
Apr 8 '13 at 23:46





Wikipedia, at least, seems to use the lowercase letter at the beginning of a sentence, for example see the article on mRNA: en.wikipedia.org/wiki/MRNA

– jbeldock
Apr 8 '13 at 23:46




2




2





Apparently, the Chicago Manual of Style's 16th edition includes a new provision permitting sentences beginning with a brand name (e.g. iPad, iPod) which starts with a lowercase letter to retain the lowercase letter: chicagomanualofstyle.org/about16_rules.html. This might be analogous.

– jbeldock
Apr 8 '13 at 23:51





Apparently, the Chicago Manual of Style's 16th edition includes a new provision permitting sentences beginning with a brand name (e.g. iPad, iPod) which starts with a lowercase letter to retain the lowercase letter: chicagomanualofstyle.org/about16_rules.html. This might be analogous.

– jbeldock
Apr 8 '13 at 23:51













Yeah, I use the same approach as Wikipedia on this one. I am, however, curious if there exist a correct and incorrect approach. I don't think the iPad rule applies since these are abbreviations rather than names, but it's an interesting one nonetheless.

– joelostblom
Apr 8 '13 at 23:58





Yeah, I use the same approach as Wikipedia on this one. I am, however, curious if there exist a correct and incorrect approach. I don't think the iPad rule applies since these are abbreviations rather than names, but it's an interesting one nonetheless.

– joelostblom
Apr 8 '13 at 23:58













We also see this in mathematics. Do not begin a sentence with a variable like x . Instead, re-word. Some extra meaningless word may be used. "Now x is..." or "Then x is..." or "Note x is..."

– GEdgar
yesterday







We also see this in mathematics. Do not begin a sentence with a variable like x . Instead, re-word. Some extra meaningless word may be used. "Now x is..." or "Then x is..." or "Note x is..."

– GEdgar
yesterday















This is a style issue, rather than "correctness". If you are writing for someone else (eg. a journal, then check their guidelines). If there are no such guidelines, then choose your style and be consistent.

– James Random
yesterday





This is a style issue, rather than "correctness". If you are writing for someone else (eg. a journal, then check their guidelines). If there are no such guidelines, then choose your style and be consistent.

– James Random
yesterday










3 Answers
3






active

oldest

votes


















3














Whenever you encounter a situation where a "rule" (such as begin a sentence with an upper case letter) will reduce the readability of your test (Is MESC the same as mESC?) then rewrite.
Do not try to find a loophole or a special rule that will need to be explained or justified. The meaning of your text is paramount.



There is a reason why chemistry texts do not begin a sentence about acids and bases with pH.






share|improve this answer



















  • 1





    I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

    – Andrew Cheong
    Apr 19 '13 at 20:32











  • Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

    – joelostblom
    Jun 19 '13 at 3:21





















6














According to Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers (C B E Style Manual),




Even if the editor chooses a style that calls for initial capitalization of every term, some terms should retain an initial lowercase letter. [...] 3 A standard symbol or abbreviation that begins with a lowercase letter (pH, pK', mRNA).




Also, according to apsstylemanual.org,




An abbreviation that begins with a lowercase letter, or a term that must remain lowercase should not be changed to all caps when it begins a sentence; it should not be expanded. The word following should be is lowercase unless it is a proper noun or another acronym. If possible, reword the sentence so that it does not begin with the lowercase term




I don't see anything (other than the one regarding brand names) in the Chicago Manual of Style.






share|improve this answer































    -1














    Because the original post is speaking of abbreviations, I recommend following the rule to spell out the word. For example, mRNA could become "Messenger RNA..."






    share|improve this answer










    New contributor




    Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
    Check out our Code of Conduct.





















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      3 Answers
      3






      active

      oldest

      votes








      3 Answers
      3






      active

      oldest

      votes









      active

      oldest

      votes






      active

      oldest

      votes









      3














      Whenever you encounter a situation where a "rule" (such as begin a sentence with an upper case letter) will reduce the readability of your test (Is MESC the same as mESC?) then rewrite.
      Do not try to find a loophole or a special rule that will need to be explained or justified. The meaning of your text is paramount.



      There is a reason why chemistry texts do not begin a sentence about acids and bases with pH.






      share|improve this answer



















      • 1





        I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

        – Andrew Cheong
        Apr 19 '13 at 20:32











      • Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

        – joelostblom
        Jun 19 '13 at 3:21


















      3














      Whenever you encounter a situation where a "rule" (such as begin a sentence with an upper case letter) will reduce the readability of your test (Is MESC the same as mESC?) then rewrite.
      Do not try to find a loophole or a special rule that will need to be explained or justified. The meaning of your text is paramount.



      There is a reason why chemistry texts do not begin a sentence about acids and bases with pH.






      share|improve this answer



















      • 1





        I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

        – Andrew Cheong
        Apr 19 '13 at 20:32











      • Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

        – joelostblom
        Jun 19 '13 at 3:21
















      3












      3








      3







      Whenever you encounter a situation where a "rule" (such as begin a sentence with an upper case letter) will reduce the readability of your test (Is MESC the same as mESC?) then rewrite.
      Do not try to find a loophole or a special rule that will need to be explained or justified. The meaning of your text is paramount.



      There is a reason why chemistry texts do not begin a sentence about acids and bases with pH.






      share|improve this answer













      Whenever you encounter a situation where a "rule" (such as begin a sentence with an upper case letter) will reduce the readability of your test (Is MESC the same as mESC?) then rewrite.
      Do not try to find a loophole or a special rule that will need to be explained or justified. The meaning of your text is paramount.



      There is a reason why chemistry texts do not begin a sentence about acids and bases with pH.







      share|improve this answer












      share|improve this answer



      share|improve this answer










      answered Apr 9 '13 at 2:56









      FortiterFortiter

      4,295915




      4,295915








      • 1





        I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

        – Andrew Cheong
        Apr 19 '13 at 20:32











      • Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

        – joelostblom
        Jun 19 '13 at 3:21
















      • 1





        I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

        – Andrew Cheong
        Apr 19 '13 at 20:32











      • Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

        – joelostblom
        Jun 19 '13 at 3:21










      1




      1





      I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

      – Andrew Cheong
      Apr 19 '13 at 20:32





      I side with your advice more than my own accepted answer, i.e. do away with the ambiguity altogether!

      – Andrew Cheong
      Apr 19 '13 at 20:32













      Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

      – joelostblom
      Jun 19 '13 at 3:21







      Revisiting my question, I also prefer this advice as it explains the reasoning behind the rules of acheong87's answer.

      – joelostblom
      Jun 19 '13 at 3:21















      6














      According to Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers (C B E Style Manual),




      Even if the editor chooses a style that calls for initial capitalization of every term, some terms should retain an initial lowercase letter. [...] 3 A standard symbol or abbreviation that begins with a lowercase letter (pH, pK', mRNA).




      Also, according to apsstylemanual.org,




      An abbreviation that begins with a lowercase letter, or a term that must remain lowercase should not be changed to all caps when it begins a sentence; it should not be expanded. The word following should be is lowercase unless it is a proper noun or another acronym. If possible, reword the sentence so that it does not begin with the lowercase term




      I don't see anything (other than the one regarding brand names) in the Chicago Manual of Style.






      share|improve this answer




























        6














        According to Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers (C B E Style Manual),




        Even if the editor chooses a style that calls for initial capitalization of every term, some terms should retain an initial lowercase letter. [...] 3 A standard symbol or abbreviation that begins with a lowercase letter (pH, pK', mRNA).




        Also, according to apsstylemanual.org,




        An abbreviation that begins with a lowercase letter, or a term that must remain lowercase should not be changed to all caps when it begins a sentence; it should not be expanded. The word following should be is lowercase unless it is a proper noun or another acronym. If possible, reword the sentence so that it does not begin with the lowercase term




        I don't see anything (other than the one regarding brand names) in the Chicago Manual of Style.






        share|improve this answer


























          6












          6








          6







          According to Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers (C B E Style Manual),




          Even if the editor chooses a style that calls for initial capitalization of every term, some terms should retain an initial lowercase letter. [...] 3 A standard symbol or abbreviation that begins with a lowercase letter (pH, pK', mRNA).




          Also, according to apsstylemanual.org,




          An abbreviation that begins with a lowercase letter, or a term that must remain lowercase should not be changed to all caps when it begins a sentence; it should not be expanded. The word following should be is lowercase unless it is a proper noun or another acronym. If possible, reword the sentence so that it does not begin with the lowercase term




          I don't see anything (other than the one regarding brand names) in the Chicago Manual of Style.






          share|improve this answer













          According to Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers (C B E Style Manual),




          Even if the editor chooses a style that calls for initial capitalization of every term, some terms should retain an initial lowercase letter. [...] 3 A standard symbol or abbreviation that begins with a lowercase letter (pH, pK', mRNA).




          Also, according to apsstylemanual.org,




          An abbreviation that begins with a lowercase letter, or a term that must remain lowercase should not be changed to all caps when it begins a sentence; it should not be expanded. The word following should be is lowercase unless it is a proper noun or another acronym. If possible, reword the sentence so that it does not begin with the lowercase term




          I don't see anything (other than the one regarding brand names) in the Chicago Manual of Style.







          share|improve this answer












          share|improve this answer



          share|improve this answer










          answered Apr 9 '13 at 2:09









          Andrew CheongAndrew Cheong

          45321026




          45321026























              -1














              Because the original post is speaking of abbreviations, I recommend following the rule to spell out the word. For example, mRNA could become "Messenger RNA..."






              share|improve this answer










              New contributor




              Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
              Check out our Code of Conduct.

























                -1














                Because the original post is speaking of abbreviations, I recommend following the rule to spell out the word. For example, mRNA could become "Messenger RNA..."






                share|improve this answer










                New contributor




                Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                Check out our Code of Conduct.























                  -1












                  -1








                  -1







                  Because the original post is speaking of abbreviations, I recommend following the rule to spell out the word. For example, mRNA could become "Messenger RNA..."






                  share|improve this answer










                  New contributor




                  Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                  Check out our Code of Conduct.










                  Because the original post is speaking of abbreviations, I recommend following the rule to spell out the word. For example, mRNA could become "Messenger RNA..."







                  share|improve this answer










                  New contributor




                  Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                  Check out our Code of Conduct.









                  share|improve this answer



                  share|improve this answer








                  edited yesterday





















                  New contributor




                  Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                  Check out our Code of Conduct.









                  answered yesterday









                  Fred L JohnsonFred L Johnson

                  12




                  12




                  New contributor




                  Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                  Check out our Code of Conduct.





                  New contributor





                  Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                  Check out our Code of Conduct.






                  Fred L Johnson is a new contributor to this site. Take care in asking for clarification, commenting, and answering.
                  Check out our Code of Conduct.






























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